The word “addiction” is derived from a Latin term for “enslaved by” or “bound to.” Anyone who has struggled to overcome an addiction — or has tried to help someone else to do so — understands why.
If you struggle with alcoholism, opiate dependence, psychostimulant abuse (e.g., cocaine), nicotine dependence, glucose binging and overeating, inability to focus (ADHD and other spectrum disorders), pathological gambling, excessive Internet gaming, sex addiction, and obsessive-compulsive disorder, among other repetitive known behaviors and want to change Excel Well LLC is here to help.
Early life stress including developmental trauma can play a role in one’s inclination toward alcoholism and drug addiction. (1) Results from preclinical studies indicate that alterations of the early microbial composition by way of antibiotic exposure, lack of breastfeeding, birth by Caesarean section, infection, stress exposure, and other environmental influences – coupled with the influence of host genetics – can result in long-term modulation of stress-related physiology and behaviour.(2) Early life stress can alter the production of neurosteroids especially allopregnanolone which is the calming neurosteroid that works on the GABA receptors. Yale Stress Center used progesterone in a study to increase the allopregnanolone levels in cocaine addicts with great results on reducing cravings. (3)
All of the above causes low grade inflammation which affects the neurotransmitters in the brain and in the gut which causes the dysfunctional HPA Axis and can lead to addiction.(4) So addressing the causes of the inflammation is one area to pursue if one is trying to end addiction.
Measuring the glucocorticoid receptor sensitivity is highly recommended. Specific patterns of a dysregulation of the HPA axis and GR function are found in different stress-related psychiatric entities e.g. major depression, job-related exhaustion or posttraumatic stress disorder. GR challenge tests like the dexamethasone-suppression test (DST), the dexamethasone-corticotropin-releasing hormone (dex-CRH) test or most recently the analysis of the dexamethasone-induced gene expression are employed to sensitively measure HPA axis activity in these disorders. They provide information for a stratification of phenotypic similar but neurobiological diverse psychiatric disorder.
Getting the hormones to optimal levels (high normal or slightly above) not just normal levels is very important too. Pregnenolone, Cortisol and Progesterone levels should be checked.
There is always the psychosomatic (mind over matter) issues when it comes to addictions as well so seeing a mental health professional who specializes in addiction is highly recommended. You can read Tony Robbins techniques to Changing Behaviour here.